Lysine for Immune Health
Lysine often flies under the radar when discussing immune health, but this essential amino acid plays a vital role in supporting your body’s natural defenses. Unlike some nutrients that our bodies can produce, lysine must be obtained through our diet.
When we talk about lysine in this article, we’re specifically referring to L-lysine, the biologically active form. So, how exactly does lysine benefit immune health?

Lysine's Role in Immune Function
Lysine is involved in various processes that contribute to a healthy immune response:
1. Wound Healing and Collagen Formation
2. Antibody Production and Immune Cell Activity
Lysine plays a vital role in supporting various aspects of immune function:
- Antibody Production: Lysine helps your body produce antibodies, which are proteins that recognize and neutralize harmful invaders like viruses and bacteria. In a clinical trial, individuals who received L-lysine showed increased immunoglobulin (antibody) and lymphocyte activity at infection sites [5].
- Immune Cell Activation: Lysine has been found to enhance the activity of certain white blood cells, equipping them with a strong acid to fight off pathogens [6].
3. Mineral Absorption, Especially Zinc
Lysine is essential for the absorption of minerals, including zinc, which is crucial for immune health.
- Zinc and Calcium: Zinc helps the body absorb and retain calcium, which is important for bone health and preventing osteoporosis and heart disease [7].
- Lysine and Zinc Absorption: Studies have shown that lysine binds with zinc in the intestine, facilitating its absorption [8]. Lysine also increases the concentration of compounds that transport zinc throughout the body [9].
Without sufficient lysine, your body’s ability to absorb and utilize zinc is compromised, potentially weakening your immune response.
4. Cold Sore Management
Cold sores, caused by the herpes simplex virus type 1 (HSV-1), can be a recurring nuisance. Lysine has shown promise in managing cold sores.
- Dosage: Repeated doses of over 3 grams of lysine per day have been shown to reduce cold sore symptoms [10].
- Caution: If you have cardiovascular issues, consult your doctor before using high doses of lysine.
Boosting Your Lysine Intake
Lysine is abundant in various protein-rich foods, including:
- Chicken and beef
- Shrimp and fish
- Milk and dairy products
- Potatoes and peppers
- Nuts, seeds, and legumes
For infections and cold sores, topical lysine ointments can also be effective [11].
Support Your Immune System with Lysine
Lysine is an essential amino acid that plays a vital role in supporting various aspects of immune function, from wound healing and antibody production to mineral absorption and cold sore management. Ensure you’re getting enough lysine through your diet or supplementation to keep your immune system strong and resilient.
Cites and Sources
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[1] - Guo, S., & DiPietro, L. (2010). Factors affecting wound healing. Journal of Dental Research, 89(3), 219–229. https://doi.org/10.1177/0022034509359125
[2] - Yamauchi, M., & Sricholpech, M. (2012). Lysine post-translational modifications of collagen. Essays in Biochemistry, 52, 113–133. https://doi.org/10.1042/bse0520113
[3] - Spallotta, F., Cencioni, C., Straino, S., Sbardella, G., Castellano, S., Capogrossi, M. C., Martelli, F., & Gaetano, C. (2013). Enhancement of lysine acetylation accelerates wound repair. Communicative & Integrative Biology, 6(5), e25466. https://doi.org/10.4161/cib.25466
[4] - Campos, A. C., Groth, A. K., & Branco, A. B. (2008). Assessment and nutritional aspects of wound healing. Current Opinion in Clinical Nutrition & Metabolic Care, 11(3), 281–288. https://doi.org/10.1097/mco.0b013e3282fbd35a
[5] - Effects of lysine-arginine association on immune functions in patients with recurrent infections. (1995). PubMed. https://pubmed.ncbi.nlm.nih.gov/7555612/
[6] - Lysine-arginine association and human neutrophil function: enhancement of functions related to microbicidal activity. (1993). PubMed. https://pubmed.ncbi.nlm.nih.gov/8077088/
[7] - Shimomura, A., Matsui, I., Hamano, T., Ishimoto, T., Katou, Y., Takehana, K., Inoue, K., Kusunoki, Y., Mori, D., Nakano, C., Obi, Y., Fujii, N., Takabatake, Y., Nakano, T., Tsubakihara, Y., Isaka, Y., & Rakugi, H. (2014). Dietary L-Lysine prevents arterial calcification in Adenine-Induced uremic rats. Journal of the American Society of Nephrology, 25(9), 1954–1965. https://doi.org/10.1681/asn.2013090967
[8] - Cheng, J., Kornegay, E. T., & Schell, T. (1998). Influence of dietary lysine on the utilization of zinc from zinc sulfate and a zinc-lysine complex by young pigs. Journal of Animal Science, 76(4), 1064. https://doi.org/10.2527/1998.7641064x
[9] - Gibson, Rosalind S, Principles Of Nutritional Assessment (New York, NY, 2005; online edn, Oxford Academic, 31 Oct. 2023), https://doi.org/10.1093/oso/9780195171693.001.0001, accessed 16 Oct. 2024.
[10] - Mailoo, V. J., & Rampes, S. (2017, June 1). Lysine for herpes simplex prophylaxis: A review of the evidence. https://pmc.ncbi.nlm.nih.gov/articles/PMC6419779/
[11] - Mulder, G. D., Patt, L. M., Sanders, L., Rosenstock, J., Altman, M. I., Hanley, M. E., & Duncan, G. W. (1994). Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl‐l‐histidyl‐l‐lysine copper. Wound Repair and Regeneration, 2(4), 259–269. https://doi.org/10.1046/j.1524-475x.1994.20406.x